Can you take Gabapentin with Tylenol?

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Written By Dr. Marcus Yu Bin Pai

MD, PhD. Physical Medicine & Rehabilitation Physician from São Paulo - Brazil. Pain Fellowship in University of São Paulo.

Gabapentin and Tylenol, widely used medications, each play a significant role in pain management. Gabapentin, typically prescribed for nerve pain and seizures, and Tylenol, a common over-the-counter pain reliever, are often inquired about for combined use.

According to the drug interaction report from, there are no known interactions between gabapentin and Tylenol [1]. However, it’s always a good idea to consult with your healthcare provider before taking any new medications or combinations of medications.

How does the combination of Gabapentin and Tylenol affect the body?

Gabapentin and Tylenol affect the body in different ways.

Gabapentin works by affecting the nervous system to reduce nerve pain and seizures. It is believed to alter the transmission of certain neurotransmitters in the brain, thereby reducing pain signals.

Tylenol, on the other hand, works primarily in the brain to block the production of prostaglandins, which are chemicals that cause pain and inflammation.

When taken together, they work in tandem to provide pain relief; Gabapentin targets nerve pain specifically, while Tylenol addresses a broader range of pain symptoms.

This combination can be particularly effective for conditions where both nerve pain and general pain are present.

Are there drug interactions between Gabapentin and Tylenol?

There are no known significant drug interactions between these two medications[1][2][5][6]. However, each of these medications can interact with other drugs, so it’s important to be aware of potential interactions if you’re taking other medications[1].

Gabapentin and Tylenol can be taken together to manage pain.

In fact, a study from Yale University found that people who took both drugs before chest surgery didn’t need as high doses of opioid-based pain killers afterward compared to those who didn’t take either medication pre-surgery[1]. Another study found that when acetaminophen was combined with gabapentin, the time of first rescue analgesic consumption was higher compared to the patients who consumed gabapentin alone, indicating that gabapentin might have potentiated the analgesic effect of acetaminophen[4].

However, it’s important to note that if gabapentin makes you sleepy, you might want to avoid Tylenol PM, which contains diphenhydramine, an ingredient that can also make people drowsy and have more serious side effects in older individuals[1][3][5].

Are there any specific conditions where combining these medications is advised or contraindicated?

The combination of Gabapentin and Tylenol is often advised for conditions involving both nerve pain and general pain, such as diabetic neuropathy, post-herpetic neuralgia, or fibromyalgia.

However, it is contraindicated in patients with certain conditions. For example, individuals with severe liver disease should avoid Tylenol due to the risk of liver toxicity.

Similarly, Gabapentin should be used cautiously in individuals with kidney impairment, as it is excreted through the kidneys.

Additionally, combining these medications is not recommended for individuals who have a history of substance abuse or dependence, as Gabapentin has the potential for misuse.

Potential side effects

It’s important to follow dosage instructions carefully and to consult with a healthcare provider, especially if you have pre-existing liver conditions or consume alcohol regularly, as these factors can elevate the risk of liver damage.

What should I discuss with my doctor before taking Gabapentin with Tylenol?

Before taking Gabapentin with Tylenol, it is important to discuss your complete medical history with your doctor. This includes any past or current liver or kidney issues, history of substance abuse, allergic reactions to medications, and other medications or supplements you are currently taking.

It’s also crucial to discuss the nature of your pain, any previous treatments you’ve tried, and your current pain management goals.

Your doctor needs this information to determine the appropriateness of this combination for your specific situation and to tailor the dosage and treatment plan to your needs.

As always, before starting any new medication or combining medications, it’s best to consult with your healthcare provider or pharmacist to ensure it’s safe for your specific health situation[5][6].


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MD, PhD. Physical Medicine & Rehabilitation Physician from São Paulo - Brazil. Pain Fellowship in University of São Paulo.

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